Urinary tract infections per se do not cause end-stage kidney disease

Pediatric Nephrology, Volume 12, Issue 3: Pages 210-213, April 1998.

Sreenarasimhaiah S, Hellerstein S.

Section of Nephrology, The Children's Mercy Hospital, The University of Missouri School of Medicine, Kansas City 64108, USA.


The objective of this study was to determine the frequency with which urinary tract infection (UTI) in the absence of concomitant underlying abnormalities caused end-stage renal disease (ESRD). The records of 102 patients with ESRD (disease necessitating dialysis and/or transplant) seen at Children's Mercy Hospital during a 10-year period (1986- 1995) were reviewed. Obstructive uropathy, aplastic/hypoplastic/dysplastic kidneys, polycystic kidney disease, congenital nephrotic syndrome, acquired glomerulonephritis, idiopathic interstitial nephritis, hemolytic uremic syndrome, and a variety of systemic conditions were the cause of ESRD in 99 children; 3 children had reflux nephropathy, 1 of whom had no history of a UTI and another who had a single, afebrile UTI. A girl with a history of recurrent UTIs since 4 years of age had an elevated serum creatinine and grade II-III bilateral vesicoureteric reflux when evaluated at 8 years of age. She had ureteral reimplantations and control of the infections, but progressed to ESRD. This child appears to be the only 1 of 102 children who developed ESRD because of acquired renal injury in which UTIs were an important contributing factor.

PMID: 9630039 [PubMed - indexed for MEDLINE]


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